ME241b : Multiple malignant melanoma tissue array with adjacent normal skin tissue, including TNM and clinical stage, 12 cases/24 cores, replacing ME241a
  • $55.00
Microarray Panel Multiple malignant melanoma tissue microarray with adjacent normal skin tissue, containing 10 cases of malignant melanoma, plus 2 adjacent normal skin tissue, duplicate cores per case
Cores 24

Cases 12
Row number 4
Column number 6
Core Diameter (mm) 1.5
Thickness (┬Ám) 5
Tissue Array Type FFPE
Species Human
Applications Routine histology procedures including Immunohistochemistry (IHC) and In Situ Hybridization (ISH), protocols which can be found at our support page.
Mouseover and click individual cores to view high resolution images.
Slide Label: US Biomax, Inc. Tissue Array
123456 
AEsoEsoSkiSki Pa Pa 
BRecRecRecRecAnuAnu 
CRecRecRecRecRecRec 
DRecRecSkiSkiSkiSkiMarked point
Legend: Pa - Parotid gland, Anu - Anus, Eso - Esophagus, Rec - Rectum, Ski - Skin

- Malignant tumor, - Malignant tumor, - Malignant tumor (stage II), - NAT

Specification Sheet (Sortable), tissue IDs are available in exported Excel files.

TNM grading:

AJCC-TNM classification for mucosal melanoma of the head and neck

T3 Mucosal disease
Primary Tumour
T3Mucosal disease
T4a Moderately advanced disease. Tumour involving deep soft tissue, cartilage, one, or overlying skin.
T4bVery advanced disease. Tumour involving brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space or mediastinal structures
Regional lymph nodes
NXRegional lymph nodes cannot be assessed
N0No regional lymph node metastases
N1Regional lymph node metastases present

Clinical stage
Stage IIIT3N0M0
Stage IVAT4aN0M0
T3-T4aN1M0
Stage IVBT4bAny NM0
Stage IVCAny TAny NM1

Vulvovaginal mucosal melanoma
Vulval melanomas are staged using the same AJCC-TNM classification as the table above. There is no staging system for vaginal melanoma, so a simplified clinical staging system can be used to categorise these melanomas.
Vaginal melanoma
Stage IClinically localized disease
Stage IIRegional nodal involvement
Stage IIIDistant metastatic involvement

Anorectal mucosal melanoma
Anorectal mucosal melanoma is staged using the same simplified staging system as vaginal melanoma.
Anorectal mucosal melanoma
Stage IClinically localized disease
Stage IIRegional nodal involvement
Stage IIIDistant metastatic involvement
Melanoma of the skins
Primary tumor (T)
* TX: Primary tumor cannot be assessed (e.g., shave biopsy or regressed melanoma)
* T0: No evidence of primary tumor
* Tis: Melanoma in situ
* T1: Tumor 1.0 mm or less in thickness with or without ulceration
  * T1a: Tumor 1.0 mm or less in thickness and Clarks level II or III, no ulceration
  * T1b: Tumor 1.0 mm or less in thickness and Clarks level IV or V or with ulceration
* T2: Tumor more than 1.0 mm but not more than 2.0 mm in thickness with or without ulceration
  * T2a: Tumor more than 1.0 mm but not more than 2.0 mm in thickness, no ulceration
  * T2b: Tumor more than 1.0 mm but not more than 2.0 mm in thickness, with ulceration
* T3: Tumor more than 2.0 mm but not more than 4 mm in thickness with or without ulceration
  * T3a: Tumor more than 2.0 mm but not more than 4 mm in thickness, no ulceration
  * T3b: Tumor more than 2.0 mm but not more than 4 mm in thickness, with ulceration
* T4: Tumor more than 4.0 mm in thickness with or without ulceration
  * T4a: Tumor more than 4.0 mm in thickness, no ulceration
  * T4b: Tumor more than 4.0 mm in thickness, with ulceration


Regional lymph nodes (N)

* NX: Regional lymph nodes cannot be assessed
* N0: No regional lymph node metastasis
* N1: Metastasis to 1 lymph node
  * N1a: Clinically occult (microscopic) metastasis
  * N1b: Clinically apparent (macroscopic) metastasis
* N2: Metastasis to 2 or 3 regional nodes or intralymphatic regional metastasis without nodal metastases
  * N2a: Clinically occult (microscopic) metastasis
  * N2b: Clinically apparent (macroscopic) metastasis
  * N2c: Satellite or in transit metastasis without nodal metastasis
* N3: Metastasis in 4 or more regional nodes, or matted lymph nodes, or in transit metastasis or satellite(s) with metastatic regional node(s)
Note: Micrometastases are diagnosed after elective or sentinel lymphadenectomy; macrometastases are defined as clinically detectable lymph nodes metastases confirmed by therapeutic lymphadenectomy, or when any lymph node metastasis exhibits gross extracapsular extension.
Distant Metastasis (M)
* MX: Distant metastasis cannot be assessed
* M0: No distant metastasis
* M1: Distant metastasis
  * M1a: Metastasis to skin, subcutaneous tissues, or distant lymph nodes
  * M1b: Metastasis to lung
  * M1c: Metastasis to all other visceral sites or distant metastasis at any site associated with an elevated serum lactic dehydrogenase (LDH)

Stage Groupings
Stage 0
  Tis, N0, M0
Stage IA
   T1a, N0, M0
Stage IB
   T1b, N0, M0
   T2a, N0, M0
Stage IIA
  T2b, N0, M0
  T3a, N0, M0
Stage IIB
  T3b, N0, M0
  T4a, N0, M0
Stage IIC
  T4b, N0, M0
Stage III
  Any T, N1, M0
   Any T, N2, M0
  Any T, N3, M0
Stage IV
  Any T, any N, M1

Find overlapping cases with this tissue array:
 

Write a review

Please login or register to review

Tags: Duplicate cores per case, Stage (TNM), With adjacent normal, Multiple organs