ME1004f : Malignant melanoma, metastatic malignant melanoma and nevus tissue array, including TNM and clinical stage, 100 cases/100 cores, replacing ME1004e
  • $255.00
Microarray Panel Malignant melanoma, metastatic malignant melanoma and nevus tissue microarray, containing 62 cases of malignant melanoma, 20 metastatic malignant melanoma and 18 nevus tissue, single core per case
Cores 100

Cases 100
Row number 10
Column number 10
Core Diameter (mm) 1
Thickness (┬Ám) 5
Quality control H&E and IHC confirmed
Tissue Array Type FFPE
Species Human
Applications Routine histology procedures including Immunohistochemistry (IHC) and In Situ Hybridization (ISH), protocols which can be found at our support page.
Mouseover and click individual cores to view high resolution images.
Slide Label: US Biomax, Inc. Tissue Array
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ASkiSkiSkiSkiSkiSkiSkiSkiSkiSki 
BSkiSkiSkiSkiSkiSkiSkiSkiSkiSki 
CSkiSkiSkiSkiSkiSkiSkiSkiSkiSki 
DSkiSkiSkiSkiSkiSkiSkiSkiVulVul 
EVulVulVulVulRecRecRecRecRecRec 
FRecRecRecRecRecStoStoEsoEsoInt 
GIntOraLymLymLymLymLymLymLymLym 
HLymLymLymLymLymLymLymLymLymLym 
ILymLymSkiSkiSkiSkiSkiSkiSkiSki 
JSkiSkiSkiSkiSkiSkiSkiSkiSkiSkiMarked point
Legend: Eso - Esophagus, Int - Intestine, Lym - Lymph node, Ora - Oral cavity, Rec - Rectum, Ski - Skin, Sto - Stomach, Vul - Vulva

- Benign tumor, - Malignant tumor, - Malignant tumor, - Malignant tumor (stage I), - Malignant tumor (stage II), - Malignant tumor (stage IIA), - Malignant tumor (stage IIB), - Malignant tumor (stage IIC), - Malignant tumor (stage III), - Malignant tumor (stage IV)

Specification Sheet (Sortable), tissue IDs are available in exported Excel files.

TNM grading:

AJCC-TNM classification for mucosal melanoma of the head and neck

T3 Mucosal disease
Primary Tumour
T3Mucosal disease
T4a Moderately advanced disease. Tumour involving deep soft tissue, cartilage, one, or overlying skin.
T4bVery advanced disease. Tumour involving brain, dura, skull base, lower cranial nerves (IX, X, XI, XII), masticator space, carotid artery, prevertebral space or mediastinal structures
Regional lymph nodes
NXRegional lymph nodes cannot be assessed
N0No regional lymph node metastases
N1Regional lymph node metastases present

Clinical stage
Stage IIIT3N0M0
Stage IVAT4aN0M0
T3-T4aN1M0
Stage IVBT4bAny NM0
Stage IVCAny TAny NM1

Vulvovaginal mucosal melanoma
Vulval melanomas are staged using the same AJCC-TNM classification as the table above. There is no staging system for vaginal melanoma, so a simplified clinical staging system can be used to categorise these melanomas.
Vaginal melanoma
Stage IClinically localized disease
Stage IIRegional nodal involvement
Stage IIIDistant metastatic involvement

Anorectal mucosal melanoma
Anorectal mucosal melanoma is staged using the same simplified staging system as vaginal melanoma.
Anorectal mucosal melanoma
Stage IClinically localized disease
Stage IIRegional nodal involvement
Stage IIIDistant metastatic involvement
Melanoma of the skins
Primary tumor (T)
* TX: Primary tumor cannot be assessed (e.g., shave biopsy or regressed melanoma)
* T0: No evidence of primary tumor
* Tis: Melanoma in situ
* T1: Tumor 1.0 mm or less in thickness with or without ulceration
  * T1a: Tumor 1.0 mm or less in thickness and Clarks level II or III, no ulceration
  * T1b: Tumor 1.0 mm or less in thickness and Clarks level IV or V or with ulceration
* T2: Tumor more than 1.0 mm but not more than 2.0 mm in thickness with or without ulceration
  * T2a: Tumor more than 1.0 mm but not more than 2.0 mm in thickness, no ulceration
  * T2b: Tumor more than 1.0 mm but not more than 2.0 mm in thickness, with ulceration
* T3: Tumor more than 2.0 mm but not more than 4 mm in thickness with or without ulceration
  * T3a: Tumor more than 2.0 mm but not more than 4 mm in thickness, no ulceration
  * T3b: Tumor more than 2.0 mm but not more than 4 mm in thickness, with ulceration
* T4: Tumor more than 4.0 mm in thickness with or without ulceration
  * T4a: Tumor more than 4.0 mm in thickness, no ulceration
  * T4b: Tumor more than 4.0 mm in thickness, with ulceration


Regional lymph nodes (N)

* NX: Regional lymph nodes cannot be assessed
* N0: No regional lymph node metastasis
* N1: Metastasis to 1 lymph node
  * N1a: Clinically occult (microscopic) metastasis
  * N1b: Clinically apparent (macroscopic) metastasis
* N2: Metastasis to 2 or 3 regional nodes or intralymphatic regional metastasis without nodal metastases
  * N2a: Clinically occult (microscopic) metastasis
  * N2b: Clinically apparent (macroscopic) metastasis
  * N2c: Satellite or in transit metastasis without nodal metastasis
* N3: Metastasis in 4 or more regional nodes, or matted lymph nodes, or in transit metastasis or satellite(s) with metastatic regional node(s)
Note: Micrometastases are diagnosed after elective or sentinel lymphadenectomy; macrometastases are defined as clinically detectable lymph nodes metastases confirmed by therapeutic lymphadenectomy, or when any lymph node metastasis exhibits gross extracapsular extension.
Distant Metastasis (M)
* MX: Distant metastasis cannot be assessed
* M0: No distant metastasis
* M1: Distant metastasis
  * M1a: Metastasis to skin, subcutaneous tissues, or distant lymph nodes
  * M1b: Metastasis to lung
  * M1c: Metastasis to all other visceral sites or distant metastasis at any site associated with an elevated serum lactic dehydrogenase (LDH)

Stage Groupings
Stage 0
  Tis, N0, M0
Stage IA
   T1a, N0, M0
Stage IB
   T1b, N0, M0
   T2a, N0, M0
Stage IIA
  T2b, N0, M0
  T3a, N0, M0
Stage IIB
  T3b, N0, M0
  T4a, N0, M0
Stage IIC
  T4b, N0, M0
Stage III
  Any T, N1, M0
   Any T, N2, M0
  Any T, N3, M0
Stage IV
  Any T, any N, M1

Find overlapping cases with this tissue array:
 

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Tags: Metastasis, Stage (TNM), Single core per case