US Biomax, Inc.

FMC402d

Multiple organ cancer frozen tissue array, with multiple organ normal tissue, including pathology grade, 40 cases/40 cores, replacing FMC402c

/
Microarray Panel:Multiple organ carcinoma frozen tissue microarray, containing 20 normal tissue (stomach, duodenum, small intestine, colon, parotid gland, thyroid gland, pancreas, prostate, aorta, testis, greater omentum, breast, lymph node, skin, medulla oblongata, spleen, uterus, vagina, bladder and nerve) and 20 cases of carcinoma (1 each of colon adenocarcinoma, esophagus squamous cell carcinoma, soft tissue giant cell tumor, kidney clear cell carcinoma, liver hepatocellular carcinoma, skin squamous cell carcinoma, testis seminoma, lung adenocarcinoma and lung squamous cell carcinoma, 2 stomach adenocarcinoma, 6 ovary adenocarcinoma, 3 breast invasive ductal carcinoma), single core per case
Cores:40
Cases:40
Layout:8 cols × 5 rows
Core Diameter:1.5 mm
Thickness:5 µm
Quality Control:H&E and IHC confirmed
Applications:

Routine histology procedures including Immunohistochemistry (IHC) and In Situ Hybridization (ISH), protocols which can be found at our support page.

Notes:Tissues were snap frozen in liquid nitrogen immediately after excision and were embedded in OCT. The array sections are 5-8 µm in thickness, mounted on positively charged glass slides, and briefly fixed by cold acetone.


Microarray Panel Display

 
Slide Label: US Biomax, Inc. Tissue Array
12345678
A Sto Duo Sma Col Par Thy Pan Pro
B Aor Tes Gre Bre Lym Ski Med Spl
C Ute Vag Bla Ner Col Eso Sto Sto
D Ova Ova Ova Ova Ova Sof Kid Liv
E Ova Bre Bre Bre Ski Tes Lun Lun
Legend: Aor - Aorta, Bla - Bladder, Bre - Breast, Col - Colon, Duo - Duodenum, Eso - Esophagus, Gre - Greater omentum, Kid - Kidney, Liv - Liver, Lun - Lung, Lym - Lymph node, Med - Medulla oblongata, Ner - Nerve, Ova - Ovary, Pan - Pancreas, Par - Parotid gland, Pro - Prostate, Ski - Skin, Sma - Small intestine, Sof - Soft tissue, Spl - Spleen, Sto - Stomach, Tes - Testis, Thy - Thyroid gland, Ute - Uterus, Vag - Vagina

- Malignant tumor, - Normal tissue

Specification Sheet

Pos No. Sex Age Organ Pathology diagnosis Grade Type †
A1 1 M 35 Stomach Normal stomach tissue Normal
A2 2 M 28 Duodenum Normal duodenum tissue Normal
A3 3 M 35 Small intestine Normal small intestine tissue Normal
A4 4 M 35 Colon Normal colon tissue Normal
A5 5 M 40 Parotid gland Normal parotid gland tissue Normal
A6 6 M 40 Thyroid gland Normal thyroid gland tissue Normal
A7 7 M 42 Pancreas Normal pancreas tissue with part autolysis Normal
A8 8 M 25 Prostate Normal prostate tissue Normal
B1 9 M 28 Aorta Normal aorta wall tissue Normal
B2 10 M 40 Testis Normal testis tissue Normal
B3 11 M 40 Greater omentum Normal greater omentum tissue Normal
B4 12 F 52 Breast Normal breast tissue Normal
B5 13 M 35 Lymph node Normal lymph node tissue Normal
B6 14 M 38 Skin Normal skin tissue Normal
B7 15 M 35 Medulla oblongata Normal medulla oblongata tissue Normal
B8 16 M 25 Spleen Normal spleen tissue Normal
C1 17 F 38 Uterus Normal cervix tissue Normal
C2 18 F 46 Vagina Normal vagina tissue Normal
C3 19 M 25 Bladder Normal bladder tissue Normal
C4 20 M 38 Nerve Normal peripheral nerve tissue Normal
C5 21 F 60 Colon Adenocarcinoma 3 Malignant
C6 22 M 46 Esophagus Squamous cell carcinoma 1 Malignant
C7 23 F 61 Stomach Adenocarcinoma 3 Malignant
C8 24 M 36 Stomach Adenocarcinoma 3 Malignant
D1 25 F 49 Ovary Adenocarcinoma 2 Malignant
D2 26 F 61 Ovary Adenocarcinoma Malignant
D3 27 F 55 Ovary Adenocarcinoma 2 Malignant
D4 28 F 51 Ovary Adenocarcinoma 2 Malignant
D5 29 F 35 Ovary Adenocarcinoma 2 Malignant
D6 30 M 45 Soft tissue Giant cell tumor Malignant
D7 31 M 54 Kidney Clear cell carcinoma 1 Malignant
D8 32 M 57 Liver Hepatocellular carcinoma 2 Malignant
E1 33 F 51 Ovary Adenocarcinoma 2 Malignant
E2 34 F 45 Breast Invasive ductal carcinoma 1 Malignant
E3 35 F 33 Breast Invasive ductal carcinoma 1 Malignant
E4 36 F 51 Breast Invasive ductal carcinoma 2 Malignant
E5 37 M 63 Skin Squamous cell carcinoma 1 Malignant
E6 38 M 37 Testis Seminoma Malignant
E7 39 M 62 Lung Adenocarcinoma 3 Malignant
E8 40 M 44 Lung Squamous cell carcinoma with necrosis (sparse) 2 Malignant

† For precise diagnosis, refer to pathology description.

**The grade 1-3 (or I-III) in Pathology Diagnosis is equivalent to well-differentiated, moderately-differentiated or poorly differentiated, respectively, under microscope.
Grade 1 or well-differentiated: Cells appear normal and are not growing rapidly.
Grade 2 or moderately-differentiated: Cells appear slightly different than normal.
Grade 3 or poorly differentiated: Cells appear abnormal and tend to grow and spread more aggressively.
Grade 4 or undifferentiated: *(for certain tumors), features are not significantly distinguishing to make it look any different from undifferentiated cancers which occur in other organs.

TNM Grading

Primary tumor (T)

  • TX: Primary tumor cannot be assessed
  • T0: No evidence of primary tumor
  • Tis: Intraductal carcinoma, lobular carcinoma in situ, or Paget's disease of the nipple with no associated invasion of normal breast tissue
    • Tis (DCIS): Ductal carcinoma in situ
    • Tis (LCIS): Lobular carcinoma in situ
    • Tis (Paget's): Paget's disease of the nipple with no tumor. [Note: Paget's disease associated with a tumor is classified according to the size of the tumor.]
  • T1: Tumor 2.0 cm or less in greatest dimension
    • T1mic: Microinvasion 0.1 cm or less in greatest dimension
    • T1a: Tumor more than 0.1 but not more than 0.5 cm in greatest dimension
    • T1b: Tumor more than 0.5 cm but not more than 1.0 cm in greatest dimension
    • T1c: Tumor more than 1.0 cm but not more than 2.0 cm in greatest dimension
  • T2: Tumor more than 2.0 cm but not more than 5.0 cm in greatest dimension
  • T3: Tumor more than 5.0 cm in greatest dimension
  • T4: Tumor of any size with direct extension to (a) chest wall or (b) skin, only as described below.
    • T4a: Extension to chest wall, not including pectoralis muscle
    • T4b: Edema (including peau d'orange) or ulceration of the skin of the breast, or satellite skin nodules confined to the same breast
    • T4c: Both T4a and T4b
    • T4d: Inflammatory carcinoma.
  • Memory Aid for Primary tumor: The two numbers to remember are 2.0 and 5.0
    • T1 is no larger than 2.0 cm
    • T2 > 2.0 - 5.0 cm
    • T3 > 5.0 cm

Regional lymph nodes (N)

  • NX: Regional lymph nodes cannot be assessed (e.g., previously removed)
  • N0: No regional lymph node metastasis
  • N1: Metastasis to movable ipsilateral axillary lymph node(s)
  • N2: Metastasis to ipsilateral axillary lymph node(s) fixed or matted, or in clinically apparent* ipsilateral internal mammary notes in the absence of clinically evident lymph node metastasis
    • N2a: Metastasis in ipsilateral axillary lymph nodes fixed to one another (matted) or to other structures
    • N2b: Metastasis only in clinically apparent* ipsilateral internal mammary nodes and in the absence of clinically evident axillary lymph node metastasis.
  • N3: Metastasis in ipsilateral infraclavicular lymph node(s) with or without axillary lymph node involvement, or in clinically apparent* ipsilateral internal mammary lymph node(s) and in the presence of clinically evident axillary lymph node metastasis; or metastasis in ipsilateral supraclavicular lymph node(s) with or without axillary or internal mammary lymph node involvement
    • N3a: Metastasis in ipsilateral infraclavicular lymph node(s)
    • N3b: Metastasis in ipsilateral internal mammary lymph node(s) and axillary lymph node(s)
    • N3c: Metastasis in ipsilateral supraclavicular lymph node(s)

* [Note: Clinically apparent is defined as detected by imaging studies (excluding lymphoscintigraphy) or by clinical examination or grossly visible pathologically.]

Distant metastasis (M)

  • MX: Presence of distant metastasis cannot be assessed
  • M0: No distant metastasis
  • M1: Distant metastasis

Find overlapping cases with this tissue array: